The primary aim of this project was to assess the capacity to conduct safety studies in a netowrk of electronic health record data sources from VAC4EU and the EU PE&PV Research Network. The second study aimed to estimate the background and cumulative incidence of the flares of 10 pre-defined autoimmune diseases, while also analysing the contribution of different provenances of data. Both studies employ a retrospective, multi-database, population-based cohort design using data from 2017 up to the most recent updates.
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SAFETY-VAC - Background rates of pre-existing chronic diseases
This study aims to assess the feasibility of participating European data sources in estimating the background and cumulative incidence of 10 selected autoimmune disease flares.
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SAFETY-VAC - Immunocompromised populations
This study aims to provide a consolidated approach to identify and characterise immunocompromised populations in real-world data sources and to produce incidence and prevalence rates...
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SAFETY-VAC - Network of data sources for vaccine safety evaluation
This study aims to provide and describe a network of real-world data sources to evaluate vaccine safety signals and to assess its fitness for the...
