Designs and methods for the conduct of studies

The ADVANCE project has made inventories of existing methods for the conduct of studies and has developed new methods in areas where gaps were identified. Please find enclosed key ADVANCE deliverables outputs which may support the conduct of studies.

  • Appraisal of vaccine safety assessment methods. Download paper

  • Appraisal of coverage and benefit assessment methods. Download paper

  • Appraisal of Benefit-risk assessment methods. Download paper

  • New methods for rapid assessment of coverage, benefits and risk in EU healthcare databases. Download paper

  • White paper on methods for vaccine benefit-risk monitoring, including vaccine coverage, safety and effectiveness. Download paper

Several novel methods to estimate vaccine coverage, benefits and/or risks have already been published:

  • De Smedt et al. Bias due to differential and non-differential disease- and exposure misclassification in studies of vaccine effectiveness. See Vaccine effectiveness tool   |  Download paper

  • McDonald et al. Methodology for computing the burden of disease of adverse events following immunization. Download paper